| ncRNA name | FECH siRNA |
| ncRNA Category | siRNA |
| Disease name | choroidal neovascularization (CNV) |
| Species | Homo sapiens |
| Tissues/Cell_line | human retinal endothelial cells (HRECs) |
| Methods | immunoblot, siRNA transfection, cell proliferation assay, migration assay, tube formation assay, immunostaining, sprouting assay, NOS assay, TUNEL assay, qRT-PCR |
| Expression pattern | associated |
| Functional description | We identified the heme synthesis enzyme ferrochelatase (FECH) as necessary for angiogenesis in vitro and in vivo FECH is overexpressed in wet AMD eyes and murine choroidal neovascularization; siRNA knockdown of Fech or partial loss of enzymatic function in the Fechm1Pas mouse model reduces choroidal neovascularization. |
| PubMed ID | 28377496 |
| Year | 2017 |
| Title | Ferrochelatase is a therapeutic target for ocular neovascularization. |
| Drug-related ncRNA | NO |
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